Endocrine Abstracts

Thyroid storm is rare life-threatening clinical manifestation of endocrine dysfunction originating from excess level of thyroid hormone leading to hypermetabolic state with an incidence of 0.57-0.76/1000,000. The increase demand of metabolic activity subsequently induces, palpitations, dyspnoea, exercise intolerance and congestive heart failure. Most common cardiovascular manifestation of thyroid storm is tachycardia and atrial fibrillation occurs in up to 15% of patients. In ...

Background: Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. It is characterized by the presence of Addison’s disease along with autoimmune thyroid disease and/or type 1 diabetes. The initial presentation can be varied but some patient maybe present with subclinical hypothyroidism and later develop Addisonian crisis. The pathogenesis of Autoimmune polyglandular syndrome type 2 remains unclear, altho...

Introduction: Pituitary tumours one of the most commonly occurring intracranial neoplasms accounting for up to the 15 % of all intracranial neoplasms. Pituitary tumours are often associated with overproduction of hormones or, when they are large, they cause mass effect on surrounding neural structures which are adjacent to their typical location in the Sella turcica. Due to their multifaceted effects pituitary tumours may cause cognitive impairment due hormonal deficiency or m...

Background: Myxoedema coma although uncommon can be life-threatening in patients who are poorly compliant with levothyroxine replacement. Some of the precipitating factors include intercurrent respiratory infection, use of sedatives, and electrolyte imbalance such as hyponatremia(Wiersinga 2018). A 73-year-old man presented to the Hospital with face and tongue swelling, shortness of breath, and type 2 respiratory failure. His past medical history includes hypothyroidism, Obstr...

Introduction: Hypothyroidism presentation can be variable. Some patients are asymptomatic whilst other present with general lethargy and cold intolerance. Depending on the degree of hormone deficiency, patient can also present with by skeletal muscle involvement characterized by muscle aches and weakness (proximal myopathy). In some cases, patients with hypothyroidism will have elevated CK but this usually less that 5000Cases: 1. 46 years old was referre...